Abstract
The development of a series of novel indole-based inhibitors of 5'-inosine monophosphate dehydrogenase (IMPDH) is described. Various hydrogen bond acceptors at C-3 of the indole were explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are outlined.
MeSH terms
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Cell Division / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glucuronides / metabolism
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Humans
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Hydrogen Bonding
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IMP Dehydrogenase / antagonists & inhibitors*
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Immune System / drug effects
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Indoles / chemistry*
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Isoenzymes / antagonists & inhibitors
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Mitogens / pharmacology
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Quinolones / chemical synthesis
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Quinolones / pharmacology
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Glucuronides
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Indoles
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Isoenzymes
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Mitogens
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Quinolones
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IMP Dehydrogenase